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Blood products include three main categories: human albumin, immunoglobulin, and coagulation factors. The production process mainly includes: Precipitation preparation, Precipitation Separation (Clarification), Chromatography purification, Ultrafiltration, Virus removal /inactivation, Sterile filtration, etc.
To meet the sterile filtration requirements of the blood product industry, Cobetter provides a range of sterile filters designed to support safety and reliability in production.
| Filter Series | Features | Applications in Blood Products Industry |
Purcise? SAF Series High Flow Rate Hydrophilic Sterilizing-Grade Capsule Filters (PES membrane) | High loading and throughput; Reliable retention of bacteria and particles. | Bioburden Reduction filtration or sterilization filtration of Human serum albumin, human immunoglobulin intermediate products. |
Purcise? SLE Series Low Protein Binding Hydrophilic Sterilizing-Grade Capsule Filters (PES membrane) | Low adsorption and low leachables; Unwetted filter can be steam sterilized directly. | Final sterilization filtration of Human serum albumin, human immunoglobulin intermediate products. |
Purcise? SLT Series Low Adsorption Hydrophilic Sterilizing-Grade Capsule Filters (PES membrane) | Low cytotoxicity; Low adsorption. | Sterile filtration of coagulation factor intermediates/final products. |
Purcise? PLE Series Low Protein Binding Hydrophilic Capsule Filters (PES membrane) | Reliable retention of bacteria and particles; Low leachables; Low protein adsorption. | Buffer filtration; Bacterial reduction filtration of human serum albumin, human immunoglobulin intermediate products. |
Greclary? CHV Series High Throughput Capsule Filters (GF membrane) | Ultra-fine glass fibers as the filtration medium; Rigid fiber material, suitable for colloid filtration; High dirt-holding capacity and high retention rate; Low initial pressure drop, high flow rate, and long service time. | Prefiltration of coagulation factor intermediates. |
PFSA2 Series High Dirt Holding Capacity Filters (PP membrane) | High particle retention efficiency; Low pressure drops, high flow rates, long service life, economical and practical | Prefiltration of coagulation factor intermediates. |
The following case examples show how Cobetter filters perform in sterile filtration steps during blood product processing.
Bioburden Reduction Filtration with PLES and SAFH Filters
PLES and SAFH filters were used for bioburden reduction filtration on intermediate products from different stages of the 10% intravenous immunoglobulin (IVIG) process. The results are shown below:
Sterile Filtration with SLES Filters
SLES filters were used for final sterile filtration of human albumin and human immunoglobulin products. The results are shown below:
Sterile Filtration of Human Coagulation Factor VIII
SLTS filters were used for sterile filtration of human coagulation factor VIII final products . The results are shown below:
In the entire blood product filtration process, from early-stage prefiltration, to the bioburden reduction filtration of intermediate product before chromatography column and ultrafiltration, to sterile filtration of the final product, Cobetter provides a full range of filters for each step, offering fast, reliable and cost-effective solutions.
